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ORIGINAL ARTICLE
Year : 2021  |  Volume : 9  |  Issue : 1  |  Page : 17-24

Effects of aqueous extract of Cyperus esculentus (tiger nut) on antioxidant status and hematological indices in the heart of cadmium-induced wistar rats


1 Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
2 Department of Medical Biochemistry, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria
3 Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Benin, Benin City, Nigeria

Correspondence Address:
Dr. Silvanus Olu Innih
Department of Anatomy, School of Basic Medical Sciences, University of Benin, Benin City
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_32_20

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Background: In recent times, medicinal plants has been explored for their ameliorating effect on Cadmium induced organ toxicity in Wistar rats. Aims and Objectives: This study investigates the protective effects of aqueous extract of Cyperus esculentus (tiger nut) on cadmium-induced biochemical and histological alterations in heart of rats. Materials and Methods: Thirty male wistar rats were randomly divided into six groups (A-F). Blood samples were collected from the animals after treatment with cadmium (10mg/kg body weight) and varying doses (150, 300, 600mg/kg B.W) of aqueous extract of Cyperus esculentus for 60 days for evaluation of antioxidant status and hematological parameters. Sections of the heart and aorta were examined for histological alterations. Results: Treatment with extract of Cyperus esculentus resulted in a significant increase (P<0.05) in superoxide dismutase, catalase and gluthathione peroxidase activities and a significant reduction in malondialdehyde level when compared to the untreated animals. However, the alterations observed in the hematological parameters were not improved on treatment with Cyperus esculentus. Conclusion: Treatment with medium (300mg/kg B.W) and high (600mg/kg B.W) of Cyperus esculentus reversed the histological alterations observed in the heart and aorta of the untreated animals. The study demonstrated that aqueous extract of Cyperus esculentus can protect against oxidative stress resulting from cadmium toxicity.


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