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Year : 2020  |  Volume : 8  |  Issue : 1  |  Page : 40-43

Liver function parameters of patients on antiretroviral therapy attending al-noury specialist hospital Kano, Nigeria

1 Department of Medical Laboratory Science, Faculty of Allied Health Science, Bayero University, Kano, Nigeria
2 Department of Biochemistry, Faculty of Basic Medical Science, Bayero University, Kano, Nigeria

Correspondence Address:
Prof. Abdulhadi Sale Kumurya
Department of Medical Laboratory Science, Faculty of Allied Health Science, Bayero University, Kano
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njecp.njecp_25_19

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Context: The hallmark of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) infection is the depletion of CD4hearing cells, especially the T helper cells, resulting in impairment of cellular immune response. The introduction of antiretroviral (ARV) therapy which has changed HIV/AIDS infection into a clinically wieldy disease is a progression development. Aims: The aim of the study was to evaluate the liver function parameters of patients ARV therapy attending Al-Noury Specialist Hospital Kano, Nigeria. Settings and Design: The study is a cross-sectional prospective study. Subjects and Methods: This work evaluated the effect of fixed dose combination of stavudine, lamivudine, and nevirapine on CD4cell counts and liver function parameters of 150 adult patients with a mean age of 34 years for 1 year. The measurement of serum alkaline phosphates, billirubin, and aminotransferases was analyzed using the reflection machine. Statistical Analysis Used: Data generated were analyzed using SPSS version 20.0. Logistic regression analysis was used to identify the significant predictors. Results: Of the 150 patients enrolled for the study, only 120 (180%) of them consisting of 82 (68.3%) males and 38 (31.7%) females were consistent with respect to adherence to therapy and submission to laboratory assessment. The findings of this study showed that CD4T-Cells, bilirubin, and alkaline phosphates had statistically significant changes (P > 0.05). Conclusions: Although the treatment outcome of patients with ARV indicates good response, evidence points to severe hepatocellular damage which may become life-threatening, especially for long-term users. We therefore recommend regular livers enzyme profile assessment as part of the integrated management of HIV/AIDS patients on ARV therapy.

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