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Year : 2020  |  Volume : 8  |  Issue : 1  |  Page : 20-25

Effect of Cymbopogon citratus aqueous extract on Areca catechu-Induced lesions in the liver of adult wistar rats

Department of Anatomy, University of Benin, Benin City, Edo State, Nigeria

Correspondence Address:
Mr. Kevin Aiwanfoh Akonoafua
P. O. Box 10095, Ugbowo Headquarters, Benin City, Edo State
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/njecp.njecp_14_20

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Background: Cymbopogon citratus has been reported to possess antimicrobial, antioxidant, antimutagenic, and anticarcinogenic properties, as well as the ability to modify gene transcription while the seeds of Areca catechu are known to contain carcinogenic compounds. Aim: This study evaluated the effects of aqueous extract of C. citratus on A. catechu-induced liver injury in adult Wistar rats. Materials and Methods: Thirty rats weighing between 180 g and 250 g were obtained from the laboratory animal facility of the Department of Anatomy, University of Benin. The animals were randomly divided into six groups of five animals each. Group A served as control and received distilled water only, Group B received A. catechu only, Group C received C. citratus only, Group D received A. catechu and low dose C. citratus, Group E received A. catechu and moderate dose C. citratus, while Group F received A. catechu and high dose C. citratus. The experimental animals were acclimatizing for 2 weeks, before the administration of extracts, which was through oral gavage, for 4 weeks. The rats were sacrificed after the 4th week. Liver function tests and appropriate histological procedures were carried out. Results: Significant increases (P < 0.05) of aspartate transaminase and alanine aminotransferase levels were recorded in the group that received A. catechu only, whereas the administration of C. citratus in various doses inhibited the rise in their levels. Conclusion: Histological analysis showed that A. catechu caused inflammation and distortion of the histoarchitecture of the liver, while C. citratus attenuated these effects.

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