Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 2  |  Issue : 1  |  Page : 59-63

Hepatoprotective activity of ethanolic extract of Leea indica (Burm.f.) Merr. (Leeaceae) stem bark against paracetamol induced liver toxicity in rats


1 Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
2 Department of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

Correspondence Address:
Garima Mishra
Teerthanker Mahaveer University, Moradabad - 244001, Uttar Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-0149.135732

Rights and Permissions

Background: Liver diseases have become one of the major causes of morbidity and mortality all over the world. Among them, synthetic drug-induced liver injury is one of the most common causative factor that poses a major clinical and regulatory challenge. The herbal medicinal plants have pivotal role in management of various diseases including liver disorders. Therefore, it is inevitable to discover novel hepatoprotective agents from natural sources. Objective: To evaluate the hepatoprotective activity of ethanolic extract of Leea indica stem bark against paracetamol (PCM) induced hepatotoxicity in rats. Materials and Methods: Hepatotoxicity was induced by PCM (2 g/kg b.w., p.o.) and biochemical parameters such as serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), serum alkaline phosphatase (SALP), serum bilirubin (total and direct), and triglyceride level were estimated. Silymarin (100 mg/kg b.w.) was employed as standard hepatoprotective agent. Histopathological changes in liver were also studied. Results: The ethanolic extract (200 mg/kg and 400 mg/kg b.w.) treatment exhibited significant decrease in elevated level of serum marker enzymes, bilirubin (total and direct), and triglycerides when compared to positive control group. The ethanolic extract at dose of 400 mg/kg b.w. was found to be more potent than 200 mg/kg. Conclusion: The ethanolic extract of Leea indica bark seems to justify the promising hepatoprotective effect on PCM induced liver damage in rats.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3815    
    Printed361    
    Emailed0    
    PDF Downloaded341    
    Comments [Add]    
    Cited by others 1    

Recommend this journal