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Year : 2013  |  Volume : 1  |  Issue : 1  |  Page : 33-38

Evaluation of antidiabetic activity of ethanolic extract of Cedrus deodara (Pinaceae) stem bark in streptozotocin induced diabetes in mice

1 Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
2 Department of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

Correspondence Address:
Pradeep Singh
Department of Pharmacognosy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad - 244 001, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2348-0149.123961

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Objective: To evaluate the antidiabetic activity of ethanolic extract of bark of Cedrus deodara. Materials and Methods: Ethanolic extract of the Cedrus deodara (EECD) at dose levels of 250 mg/kg and 500 mg/kg body weight was subjected to the streptozotocin induced diabetes mice. The biochemical parameters, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), cholesterol and triglycerides were also assessed in the experimental animals. Results: The EECD exhibited significant antihyperglycemic activity and also lowers the biochemical parameters like SGPT, SGOT, cholesterol and triglycerides. The ethanolic extract at dose level of 500 mg/kg was found to be more potent than 250 mg/kg in lowering the blood glucose level, almost near to the effect of the standard drug. Conclusion: This study supports the traditional claim and the ethanolic extract of this plant could be added in traditional preparations for the ailment of various diabetes-associated complications.

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