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ORIGINAL ARTICLE
Year : 2016  |  Volume : 4  |  Issue : 1  |  Page : 6-12

Melatonin administration to castrated rats reversed the castration-induced dyslipidemia while potentiating increased testosterone production from other nontesticular sources


1 Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria
2 Department of Physiology, School of Medicine and Pharmacy, University of Rwanda College of Medicine and Health Sciences, Huye, Republic of Rwanda, East Afrcia
3 Department of Anatomy, College of Health Sciences, University of Ilorin, Ilorin, Kwara, Nigeria

Correspondence Address:
Dr. Abdullateef Isiaka Alagbonsi
Department of Physiology, School of Medicine and Pharmacy, University of Rwanda College of Medicine and Health Sciences, Huye
East Afrcia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/njecp.njecp_1_16

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Background: Castration has been shown to be associated with dyslipidemia. The present study aimed at investigating the effect of melatonin supplementation on castration-induced dyslipidemia. Materials and Methods: Twenty-five male Wistar rats were randomly divided into two surgical groups: Group I rats (n = 10) were sham-operated and then subdivided into 2 oral gavage treatment groups (n = 5 each) to receive either normal saline (1 ml/kg) or 10 mg/kg melatonin for 4 weeks. Group II rats (n = 15) were rendered bilaterally castrated and then subdivided into 3 oral gavage treatment groups (n = 5 each) to receive normal saline (1 ml/kg), 4 mg/kg melatonin, or 10 mg/kg melatonin for 4 weeks. Results: Castrated rats that received normal saline had reduced high-density lipoprotein (35.8 ± 3.8 vs. 62.37 ± 3.26 mg/dl), testosterone (0.30 ± 0.01 vs. 2.70 ± 0.20 ng/ml), estradiol (1.30 ± 0.01 vs. 2.70 ± 0.20 pg/ml) but increased low-density lipoprotein (57.90 ± 0.70 vs. 35.23 ± 0.93 mg/ml), triglycerides (158.20 ± 5.90 vs. 130.93 ± 2.96 mg/ml), total cholesterol (100.00 ± 1.70 vs. 73.67 ± 2.77 mg/ml), Castelli index (2.83 ± 0.35 vs. 1.19 ± 0.07), and had the same follicle stimulating hormone (3.86 ± 0.04 vs. 3.32 ± 0.17 mIU/ml) when compared to sham-operated rats that received normal saline, respectively. Melatonin supplements improved these parameters in normal and castrated rats, with 10 mg/kg melatonin-producing more noticeable effect. Conclusions: Melatonin administration to castrated rats reversed the castration-induced dyslipidemia while potentiating increased testosterone and estradiol production from other nontesticular sources.


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