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ORIGINAL ARTICLE
Year : 2014  |  Volume : 2  |  Issue : 1  |  Page : 49-53

Experimental studies on immunomodulatory potential of Cissus quadrangularis Linn


1 Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India
2 Pharmaceutics Research Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, India

Correspondence Address:
Aditya Ganeshpurkar
Drug Discovery Laboratory, Shri Ram Institute of Technology-Pharmacy, Jabalpur - 482 002, Madhya Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-0149.135730

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Introduction: In ancient times Cissus quadrangularis Linn. was used as a general chow item in China. The stout fleshy stem of C. quadrangularis is an edible plant found throughout the hotter parts of India, Malaya, West Africa, and Ceylon. The plant part contains a number of phytoconstituents like alkaloids, glycosides, polyphenols, flavonoids, sterols, etc. It has demonstrated antiulcer and cytoprotective properties. Aim: The present study was designed to evaluate immune-modulatory potential of C. quadrangularis. Materials and Methods: Plant material was powdered and extraction was done with ethanol phytochemical screening and estimations of phenolics and flavonoids were carried out. Acute toxicity studies were performed as per Organization for Economic Co-operation and Development (OECD) guidelines. The extract was further evaluated for immunomodulatory activity through carbon clearance test, effect on serum immunoglobulins, determination of delayed-type hypersensitivity (DTH) and phagocytosis of killed Candida albicans tests were done to determine immunoprophylactic potential. Result: Results of phytochemical and phytoanalytical tests demonstrated that C. quadrangularis is rich in polyphenolic and flavonoid content. C. quadrangularis also showed promising immunomodulatory potential on various models like DTH, carbon clearance test and effect on serum immunoglobulins. Discussion and Conclusion: These studies conclude that C. quadrangularis possess immunomodulatory activity which might be due to presence of phytochemicals like flavonoids and phenolic compounds.


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